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The intracellular targets of motion of metronidazole on anaerobes are largely unidentified. The five-nitro group of metronidazole is lowered by metabolically active anaerobes, and reports have shown that the lowered type of the drug interacts with bacterial DNA.
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Even though metronidazole has proven mutagenic exercise in quite a few in vitro assay systems, scientific studies in mammals (in vivo) have failed to demonstrate a potential for genetic damage.
Fertility research are already carried out in mice up to 6 times the encouraged human oral dose (according to mg/m²) and possess unveiled no proof of impaired fertility.
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There has been no experience to this point with the usage of METROGEL-VAGINAL in pregnant people. Metronidazole crosses the placental barrier and enters the fetal circulation fast. No fetotoxicity or teratogenicity was noticed when metronidazole was administered orally to pregnant mice at 6 instances the suggested human dose (based upon mg/m²); even so, in just one small review in which the drug was administered intraperitoneally, some intrauterine deaths were observed. The connection of those conclusions to the drug is not known.
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Specific experiments of metronidazole ranges in human milk subsequent intravaginally administered metronidazole haven't been executed. Even so, metronidazole is secreted in human milk in concentrations similar to People located in plasma subsequent oral administration of metronidazole.
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